Basic and applied research efforts are directed towards empowering patients to become co-managers of their own health facilitating smart personalised interventions including mHealth and serious games applications for rehabilitation, chronic disease management, and healthy ageing, building on augmented and mixed reality applications, capitalizing near real-time cloud-based Electronic Health Record (EHR) data, and encompassing gamification strategies, unobtrusive edge diagnostics using miniaturized system-on-chip Internet of Things (IoT) biosensors, and social robotics interactions.